Jean-Yves Sgro

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Dengue Virus protein capsid with major envelope protein E. These flaviviruses are single stranded RNA, positive-strand viruses in the family Flaviviridae with a genome of about 11,000 bases. Dengue fever and dengue hemorrhagic fever are caused by  four closely related virus serotypes transmitted by mosquitoes. Dengue fever is endemic in more than 100 countries and the World Health Organization estimates that 2.5 billion people are at risk from dengue and projects that there may be 50 million cases worldwide every year. This represents the first structure of a flavivirus which has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of individual glycoprotein E into the electron density map. The colors represent the position-specific symmetrical location on the icosahedral lattice.<br />
Rendering with radial depth cueing (color ramp) and  ambient occlusion shadowing both help distinguish and highlight surface features. View is along the 2-fold icosahedral symmetry axis. Individual, small spheres are atoms making up the proteins. Hydrogen atoms are not shown.