Jean-Yves Sgro

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3021746.JPG
Canine Parvovirus protein type 2 capsid. The single stranded DNA genome inside the capsid is not visible.  Canine Parvovirus Type 2 (CPV2) was first recognized in 1978 and spread worldwide in less than two years. CPV2 has a high rate of evolution. The two strains CPV2a and CPV2b identified in 1979 and 1984 respectively are believed to cause most cases of Canine Parvovirus infection and have replaced the original virus strain. Puppies are most susceptible, and more than 80 percent of adult dogs show no symptoms. With severe disease, dogs can die within 48-72 hours without treatment by fluids and antibiotics. Dogs who catch Parvovirus usually die from the dehydration it causes or secondary infection rather than the virus itself. CPV2 affects dogs, wolves, foxes, and other canids. The virus is 98% similar to Feline Panleukopenia (also a parvovirus) and differ only in two amino acids in the viral capsid protein VP2. Rendering is colored by radial depth-cue to highlight surface topography. View is along the 2-fold icosahedral symmetry axis. Individual, small spheres are atoms making up the proteins.