Cross-section of microvilli and a goblet cell in the human digestive tract mucosa. TEM X6000.The job of the goblet cell is to secret mucous. Goblet cells are found in higher numbers in respiratory and intestinal areas. Mucous is secreted by a goblet cell in response to irritating stimuli. Increased numbers of goblet cells are found with certain diseases such as chronic bronchitis and cystic fibrosis.