Jean-Yves Sgro

Image 18 of 44
< Prev Next >
Poliovirus Type 1 Mahoney protein capsid with receptor based on X-ray  crystallography and cryoelectron microscopy.The single stranded RNA genome inside the capsid is not visible here. Poliovirus causes Poliomyelitis, which is highly contagious and spreads easily by human-to-human contact. Most infections cause no symptoms but about 1% enter the central nervous system destroying motor neurons leading to muscle weakness and acute flaccid paralysis. The polio vaccines developed by Jonas Salk in 1952 (dead virus) and Albert Sabin (live, attenuated virus) in 1962 are credited with reducing the global number of polio cases per year from many hundreds of thousands to around a thousand. The poliovirus receptor CD155 is a transmembrane protein with 3 immuno-globulin-like extracellular domains, D1-D3. D1 is the domain recognized by the virus. The virus is colored by radial depth-cueing and ambient occlusion to highlight surface topography. View is along the 2-fold icosahedral symmetry axis. Individual, small spheres are atoms making up the proteins.